Current trends in toxicoepigenomics research, limitations and future perspective

Toxicoepigenomics is new field emerged from the combination of toxicology and epigenetics. It defined as heritable changes in gene activity induced by exposure to environment toxicant substances such heavy metals without any alterations existing nucleotide sequence. Research studies show that epigenetics plays important role development certain human diseases diabetes cancer. Hence toxicoepigenomics has evolved an area research. In targeting DNA methylation alteration a tool identify underlying causes disease exists trend current research design, but this aspect been evaluated extensively. New mechanisms microRNA (miRNA) dysregulations need be considered for future work. Furthermore, it consider different study designs application parallel vitro vivo studies. This might interesting will enable researchers fill gap designs.